The 2018 International Conference on Spreading Depolarizations will be held on September 22-24, 2018, in Boca Raton, Florida, USA, as an official satellite of the Annual Meeting of the Neurocritical Care Society (September 25-28, 2018). Both program committees have recognized this as an excellent opportunity to promote translational research and education in treatment of acute neurologic injuries.

iCSD is an annual meeting dedicated to the study of spreading depolarizations, the mass waves of cellular depolarization discovered by Aristides Leao. Depolarizations are a key pathologic mechanism in a variety of neurologic disorders and have been studied for over 70 years. Annual meetings to discuss these phenomena were initiated in 2003 with the formation of COSBID. In 2017, the meeting was re-formulated as iCSD to cultivate an open community and recognize spreading depolarizations as its own field of translational neuroscience. We welcome you to participate in iCSD2018, whether to learn or to present your latest findings from the lab or the clinic. With presentations ranging the gamut from clinical outcomes to electron microscopy, we believe you will find the ‘depth of field’ in translational flavor is unparalleled!  Follow us on Twitter https://twitter.com/COSBID

Program

Download the final iCSD2018 program (PDF).

  • SCHEDULE AT A GLANCE

    Schedule

    Saturday, September 22

    12:00 – 14:00 Registration
    14:00 – 14:10 Opening and Welcome
    14:10 – 16:10 Session 1: SD in TBI
    16:45 – 17:45 Keynote I: David Okonkwo, MD, PhD
    Cortical Spreading Depolarizations: The Next Frontier in Coma Care
    17:45 – 20:00 Welcome Reception

     

    Sunday, September 23

    07:00 – 08:00 Breakfast
    08:00 – 10:00 Session 2: SD in Cerebral Ischemia
    10:00 – 10:50 Posters and Networking 1
    10:50 – 12:30 Session 3: ECoG and EEG
    12:30 – 13:10 Lunch
    13:10 – 15:10 Session 4: SD in Injured & Normal Brain
    15:30 – 16:30 Keynote 2: Marc Simard, MD, PhD
    The Endfoot in Charge: SUR1-TRPM4 in Cerebral Ischemia
    16:30 – 17:30 Moderated Open Discussion: Which SDs are harmful?
    19:00 – 22:00 iCSD Dinner at Matteo’s of Boca Raton

     

    Monday, September 24

    07:00 – 08:00 Breakfast
    08:00 – 09:40 Oral Abstract Session 5: Mechanisms of spreading depolarizations
    09:40 – 10:00 Special Session on Historical Figures in SD Research: George Somjen
    10:00 – 10:50 Posters and Networking 2
    10:50 – 12:30 Session 6: Treatments for spreading depolarizations
    12:30 – 13:30 Lunch
    13:30 – 15:10 Session 7: Clinical neuromonitoring
    15:10 – 16:30 Keynote 3: Ari Ercole, MD, PhD­
    Neuromonitoring: From Signals to Service, via Systems and Statistics
    16:30 – 17:30 Moderated Open Discussion: What should a clinician do when SDs are observed?
    17:30 Final Announcements and Adjournment
  • KEYNOTE SPEAKERS

    Keynote Speakers
    David Okonkwo, MD, PhD, Clinical Director of the Brain Trauma Research Center, University of Pittsburgh. Dr. Okonkwo has advanced novel neuroimaging modalities for personalized management of TBI and is principal investigator of a nationally funded clinical core to study TBI pathophysiology. He has contributed as a thought-leader to many clinical research initiatives and has been one of the most proliferative contributors to COSBID research efforts.

     

    Marc Simard, MD, PhD, Professor of Neurosurgery, Pathology and Physiology, University of Maryland. Dr. Simard is known for ground-breaking research into the molecular pathophysiology of cerebral edema following stroke and cardiac arrest, including discovery of the Sur1-Trmp4 channel. His basic science insights are now being translated in active clinical trials of glibenclamide.

     

    Ari Ercole, MD, PhD, Lecturer and Consultant Anaesthetist, University of Cambridge. With a doctorate in physics, Dr. Ercole adds a unique dimension to the Brain Physics Lab that studies the relationship between volume, pressure, and blood flow in the brain and has developed the pressure-reactivity index and the concept of individual optimal cerebral perfusion pressure. Dr. Ercole also leads efforts in analysis of high-resolution ICU data and is a CENTER-TBI investigator.

  • WORKSHOPS

    Workshops
    A great benefit of partnering with the Neurocritical Care Society Annual Meeting is access to the many workshop that NCS will offer on Sept 25, the day immediately following iCSD. The full list of workshops is here. Of note, for the first time at NCS there will be a workshop on Clinical Monitoring of Spreading Depolarizations to meeting the growing demand for education in this field. The full details are below. This a great opportunity to be introduced to the basic techniques, methods for data display and interpretation, and review real clinical data. Please spread the word to interested colleagues and consider signing up! Note that it is possible to register for the workshops alone, even if you do not attend the main NCS meeting.

    Course Title: Clinical Monitoring of Spreading Depolarizations
    Course Director:     Jed Hartings, PhD
    Faculty: Jens Dreier, MD; Raimund Helbok, MD; Martin Fabricius, DMSc; Brandon Foreman; MD, FACNS
    Description: Spreading depolarizations (SD) are an emerging hot topic in neurocritical care as a critical mechanism of lesion development in stroke and TBI, and thus a potential target for precision medicine treatment. This workshop will provide an introduction to the basic skills and techniques required to monitor and diagnose SDs in patients at your institution. We will review all practical aspects of performing electrocorticography (ECoG) and EEG to monitor SDs in acute brain injury, including electrode types, electrode placement, requirements for data acquisition, data filtering and visualization, and terminology. We will cover invasive subdural strip and depth electrode techniques, as well as manifestations in scalp EEG recordings. In practical exercises with real patient recordings, participants will learn how to review data and identify SD at the bedside. The curriculum is targeted to a general audience, including physicians and researchers.

Meeting Registration

Advanced registration has closed. Onsite conference registration will be available for $250 from 12:00-13:45 on September 22 at the meeting registration desk. The off-site dinner can also be booked at that time for $70.

Lodging: Boca Raton Resort & Club

Designed by legendary architect Addison Mizner, Boca Raton Resort & Club, A Waldorf Astoria Resort has reigned as an icon of elegance for more than 80 years. Situated on 356-acres in fabled South Florida, this eclectic, private village offers the best of all worlds: an award-winning spa, championship golf and tennis, expansive beach and luxury marina – all just steps from your door.

Follow this link to make reservations, or from the U.S. call 1-888-557-6375 and mention the code iCSD2018. The room rate options are $160, $180, $210 and $310/night. The earlier you book, the better chance you have to receive your choice of room type. Note: The hotel is full on the evening of Sept. 24. You can still book for the evenings of Sept. 21, 22 and 23. Nearby alternative hotels:

Waterstone Resort & Marina
999 East Camino Real
Boca Raton, FL 33432
+1 561-368-9500
https://www.waterstoneboca.com

Hyatt Place Boca Raton/Downtown
100 E. Palmetto Park Road
Boca Raton, FL 33432
+1 561-672-7819
$119/night. Use this specific link to book your room over the meeting dates – the group code is included in the upper right hand corner date search: https://www.hyatt.com/en-US/hotel/florida/hyatt-place-boca-raton-downtown/fllzb?corp_id=G-ICSD

Travel / Flight

Here are the best recommended airports:

Fort Lauderdale/Hollywood International Airport (FLL)
Distance from hotel: 24 mi.
Drive time: 45 min.
Approximate Uber fare: $30-$39

Palm Beach International Airport (PBI)
Distance from hotel: 29 mi.
Drive time: 35 min.
Approximate Uber fare: $35-$47

Miami International Airport (MIA)
Distance from hotel: 45 mi.
Drive time: 70 min.
Approximate Uber fare: $59-$78

Sponsor Opportunities

We gratefully acknowledge our sponsors whose generous support make the meeting possible. If your company would like to participate in the International Conference on Spreading Depolarizations please contact info@cosbid.org

 

Scientific Planning Committee
Jed Hartings
Brandon Foreman
Raimund Helbok
Bill Shuttleworth
Cenk Ayata
Jens Dreier

 

Highlights of iCSD2017 | Berlin